Wang, Z., Huang, Z., Wu, Q., Zhou, J., Zhu, X., Li, Q., and Liu, Z. View abstract. 2010 Nov 9;4:e879. J.Eur.Acad.Dermatol.Venereol. Shah, S. A., DiTullio, P., Azadi, M., Shapiro, R. J., Eid, T. J., and Snyder, J. Eshghi F, Hosseinimehr SJ, Rahmani N, et al. Early research shows that applying a specific product containing acemannan, a chemical from aloe, to the tooth socket after standard treatment reduces pain and improves symptoms from dry socket more than standard treatment alone. II. Vestnik Dermatologii i Venerologii 1977;12:44-45. Compared to the more widely known Aloe vera, Aloe ferox produces 20 times more bitter sap and has higher nutrient concentrations. View abstract. Common side effects of aloe include: blood sugar (hypoglycemia) Burning and itching of the skin (infrequent) Stomach pain and cramps (high doses) Effects of oral Aloe vera on electrocardiographic and blood pressure measurements. J Dermatol.Surg.Oncol 1990;16(5):460-467. Bed sores (pressure ulcers). Wound healing. View abstract. (not just aloe, but also … Cape aloe may cause diarrhea and strong cramping. View abstract. View abstract. View abstract. 2012;2:CD008092. Effect of aloe vera gel to healing of burn wound a clinical and histologic study. Wu, J. H., Xu, C., Shan, C. Y., and Tan, R. X. Antioxidant properties and PC12 cell protective effects of APS-1, a polysaccharide from Aloe vera var. View abstract. Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Sevoflurane is used as anesthesia during surgery. Clinical and toxicological aspects of anthraquinone laxatives. View abstract. Most research shows that applying aloe gel or cream to the skin can reduce healing time in people with first- or second-degree burns. Pharmacology 1993;47(suppl 1):120-124. Other research evaluating a specific aloe-containing toothpaste (Forever Bright, Forever Living Products) shows that it works about as well as a toothpaste that contains fluoride. Rowe TD, Lovell BK, and Parks LM. Evaluation of efficacy of aloe vera in the treatment of oral submucous fibrosis - a clinical study. View abstract. Quiz: What Do You Know About Vitamin B12 Deficiency? Angiology 1985;36(8):485-492. Rahmani N, Khademloo M, Vosoughi K, Assadpour S. Effects of Aloe vera cream on chronic anal fissure pain, wound healing and hemorrhaging upon defection: a prospective double blind clinical trial. Dal'Belo SE, Gaspar LR, Maia Campos PM. View abstract. Gen.Dent. There has been one report that using the gel as standard wound therapy delayed healing. View abstract. Also, other research suggests that applying aloe gel does not seem to delay new canker sores. View abstract. Schorkhuber M, Richter M, Dutter A, et al. African Cape Aloe … Skin Res Technol. Complement Ther Med. Langmead L, Makins RJ, Rampton DS. Boudreau MD, Beland FA, Nichols JA, Pogribna M. Toxicology and carcinogenesis studies of a nondecolorized [corrected] whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study). Heliyon. Muller MJ, Hollyoak MA, Moaveni Z, et al. Thus, it is extremely essential to prevent the indiscriminate use of aloe … Sores in the mouth from injury or rubbing (traumatic oral ulcers). 2016;29(6):309-17. Contact Dermatitis 2007;57(4):278-279. Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus. Hayes, S. M. Lichen planus--report of successful treatment with aloe vera. View abstract. I. Alam S, Ali I, Giri KY, Gokkulakrishnan S, Natu SS, Faisal M, Agarwal A, Sharma H. Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. Cancer Nurs 2002;25:442-51.. View abstract. 2011;69:1571-7. Pradeep AR, Agarwal E, Naik SB. Clin Research 1987;35(3):483a. Koch A. Disphanurat W, Kaewkes A, Suthiwartnarueput W. Comparison between topical recombinant human epidermal growth factor and Aloe vera gel in combination with ablative fractional carbon dioxide laser as treatment for striae alba: A randomized double-blind trial. View abstract. International Agency for Research on Cancer (IARC). Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. Aloe vera extract 0.5% in hydrophilic cream versus aloe vera gel for the measurement of genital herpes in males. Radiology 1939;32:598-599. Use caution with cosmetic products containing A. vera gel. Planta Med 2002;68(11):957-960. View abstract. View abstract. View abstract. J Altern.Complement Med. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Effects of aloe sterol supplementation on skin elasticity, hydration, and collagen score: a 12-week double-blind, randomized, controlled trial. ENCOURAGE A HEALTHY DIGESTIVE SYSTEM: Within the “sap” of the Cape Aloe … Worthington, H. V., Clarkson, J. E., and Eden, O. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. View abstract. Other symptoms of IBS include cramping, abdominal pain, flatulence, and bloating. Oyelami OA, Onayemi A, Oyedeji OA, et al. J Acquir Immune Defic Syndr Hum Retrovirol. Lyon, France: International Agency for Research on Cancer; 2015. Bruce, S. and Watson, J. J Derm Treatment 1997;8(2):99-102. BMJ Case Rep 2012;2012. View abstract. this site complies with the HONcode standard for trustworthy health information: Coopoosamy RM, Naidoo KK. Photodermatol. How Aloe Ferox is effective for various diseases is listed in repertory format. View abstract. View abstract. Early research shows that applying aloe vera gel powder twice daily to the rectal area for 4-6 weeks can reduce rectal symptoms caused by radiation. Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects. 2005;88 Suppl 4:S173-6. 2005;24(4):438-442. Krumbiegel G and Schulz HU. Aloe vera latex. View abstract. Zhong.Yao Cai. View abstract. J Clin Epidemiol 1997;50(suppl 1):3S. Evaluation of a prescription strength 4% hydroquinone/10% L-ascorbic acid treatment system for normal to oily skin. J Oral Pathol Med 2012;41(10):755-61. The effect of aloe vera and tea tree oil mouthwashes on the oral health of school children. 2009;23:1482-4. J Coll Physicians Surg Pak. Early research suggests that applying aloe twice daily for 4-6 weeks improves dandruff. Collins EE and Collins C. Roentgen dermatitis treated with fresh whole leaf of aloe vera. 1996;2(2):271-277. View abstract. Syed TA, Cheema KM, and Ahmad SA et al. Diaper rash. Mechanism of cathartic effect. 2008;16:293-6. 2010;24:168-72. Lee, K. H., Kim, J. H., Lim, D. S., and Kim, C. H. Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne. J Amer Pharmaceut Assoc 1941;30:266-269. Native to Southern Africa, it is colloquially called ‘bitter aloe’ or ‘cape aloe’. View abstract. Eur Rev Med Pharmacol Sci 2014;18(7):1078-84. A comparative study of three Aloe species used to treat skin diseases in South African rural communities. 2012;18:2026-34. McDaniel HR, Combs C, McDaniel HR, and et al. View abstract. 2013;131(1):26-39. Vazquez, B., Avila, G., Segura, D., and Escalante, B. Antiinflammatory activity of extracts from Aloe vera gel. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Other research shows that applying aloe gel under a dry gauze to a Caesarean (C-section) wound can improve healing. 2004 Sep 1;60:171-7. J Burn Care Rehabil 1988;9:156-9. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96. No author. Taking aloe gel along with diabetes medications might cause your blood sugar to go too low. View abstract. View abstract. Radiat Oncol. J Korean Med Sci 2010;25:492-5. J Clin Pharm Ther. PLoS Negl Trop Dis. Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta-analysis. J Altern Complement Med. Wright CS. 2020;21(1):61-66. Phytomedicine 1996;3:241-3. Ann.Oncol. They are most definitely “bitter” which means they are good for the body. Studies of aloe. Mol Med Rep 2018;18(3):3537-43. doi: 10.3892/mmr.2018.9319. de Oliveira SM, Torres TC, Pereira SL, et al. Olatunya OS, Olatunya AM, Anyabolu HC, et al. No doi. Zhang Y, Liu W, Liu D, Zhao T, Tian H. Efficacy of aloe vera supplementation on prediabetes and early non-treated diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Salazar-Sanchez, N., Lopez-Jornet, P., Camacho-Alonso, F., and Sanchez-Siles, M. Efficacy of topical Aloe vera in patients with oral lichen planus: a randomized double-blind study. Dry socket (alveolar osteitis). 2012;65(2):374-378. Phillips T, Ongenae K Kanj L Slater-Freedberg J. 2005;28(6):482-485. Int J Dermatol. 2012;83:797-804. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Contact Dermatitis 1982;8(3):164-167. Phytomedicine. Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Herbal remedy-associated acute renal failure secondary to Cape aloes. J Am Podiatr.Med Assoc 1994;84(12):614-621. View abstract. 2006;29(10):25-30. Medications for diabetes (Antidiabetes drugs) interacts with ALOE. McDaniel HR and McAnalley BH. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. Aloe Fernex has higher nutrient concentrations than the more common Aloe Vera. J Med Assoc Thai. There is not enough research on the use of supplements containing cape aloe during pregnancy and breast-feeding, so consult a licensed healthcare practitioner before use or avoid use. View abstract. 2012;2:CD008762. Wounds 1995;7(5):200-202. Cape aloe leaf: I admire you for interest in your Health. Panahi Y, Sharif MR, Sharif A, et al. Reddy RL, Reddy RS, Ramesh T, Singh TR, Swapna LA, Laxmi NV. Richardson, J., Smith, J. E., McIntyre, M., Thomas, R., and Pilkington, K. Aloe vera for preventing radiation-induced skin reactions: a systematic literature review. J Altern Complement Med. Odontology. View abstract. Effects of low-dose Aloe sterol supplementation on skin moisture, collagen score and objective or subjective symptoms: 12-week, double-blind, randomized controlled trial. View abstract. Make sure to follow the specific product instructions and take as directed on the label, or consult a licensed healthcare practitioner before use. Bunyapraphatsara, N., Yongchaiyudha, S., Rungpitarangsi, V., and Chokechaijaroenporn, O. Antidiabetic activity of Aloe vera L. juice II. Heggers, J. P., Kucukcelebi, A., Listengarten, D., Stabenau, J., Ko, F., Broemeling, L. D., Robson, M. C., and Winters, W. D. Beneficial effect of Aloe on wound healing in an excisional wound model. The effects of aloe vera on wound healing in cell proliferation, migration, and viability. 1994;17:651-3. Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. View abstract. Endocr.Metab Immune.Disord Drug Targets. Comparison of aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: a randomized double-blinded clinical trial. Burns. The efficacy of oral Aloe vera for radiation induced mucositis in head and neck cancer patients: a double-blind placebo controlled study. Clinical trial of Aloe vera linn. 2010;4(6):367-377. 1995;78:403-9. View abstract. View abstract. 2018 Jan 14. doi: 10.2174/1570163815666180115093007. Ishii Y, Tanizawa H, Takino Y. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. de Witte, P. and Lemli, L. The metabolism of anthranoid laxatives. Aloe might decrease clotting of the blood. View abstract. The bio-active compounds in aloe vera might interfere with liver's detoxification process, further causing health complications. It might be safe when appropriate doses are taken orally for a short time.Aloe latex or whole-leaf extract taken orally might be unsafe and is likely unsafe in high doses. Other research suggests that wearing gloves coated in aloe improves symptoms of dry skin in women. View abstract. 1999;47(3):268-272. A case of acute liver damage after aloe vera ingestion has been reported. But more research is needed to confirm. Davis, R. H., Donato, J. J., Hartman, G. M., and Haas, R. C. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. Rev Cuba Med Gen Integr 1993;9:43-51. J Dermatolog Treat 2014;25(2):123-9. J Ethnopharmacol 1999;68:3-37. Early research suggests that applying a cream containing aloe gel and olive oil three times daily for 10 days reduces the severity of diaper rash in children younger than 3-years-old. Efficacy of aloe vera gel in the treatment of vulval lichen planus. (check all that apply), What factors are most important to you? Amer J Clin Pathol 1990;94(4):516-517. View abstract. 2002 Mar;39(3):E13. View abstract. Alvagel as a therapeutic agent in the treatment of roentgen and radium burns. 1996;3(3):241-243. 11-15-2010;67(22):1942-1946. View abstract. The gel may cause burning sensations in dermabraded skin, and redness and itching also can occur. View abstract. Panahi Y, Davoudi SM, Sahebkar A, et al. Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Aloe vera dermal wound gel is associated with a delay in wound healing. Singh, R. P., Dhanalakshmi, S., and Rao, A. R. Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice. Also, eating 30-40 mL of aloe gruel does not improve immune function in people with HIV compared to antiretroviral therapy. Fitoterapia 2007;78(3):219-222. Early research suggests that, when given with standard chemotherapy, three daily doses of a mixture containing fresh aloe leaves and honey dissolved in alcohol increases the number of patients with lung cancer who are able to heal completely, partially, or maintain control of their disease when compared to just chemotherapy alone. Cell Mol.Life Sci 2006;63(24):3083-3089. Eur J Int Med 2006;17:589. Quintessence Int 2012;43(9):793-800. Melanoma Res 2005;15(6):489-494. Some research shows that applying an aloe cream to hemorrhoid-related wounds can help the wounds heal and provide some pain relief. Cochrane Database Syst Rev. 1994;17:495-7. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Further observations on the use of Aloe vera leaf in the treatment of third degree x-ray reactions. HIV/AIDS. Nutrition. (check all that apply). Williams MS, Burk M, Loprinzi CL, et al. The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing. View abstract. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Agarwal, O. P. Prevention of atheromatous heart disease. Food and Drug Administration, HHS. Inhibition of Cl- channels as a possible base of laxative action of certain anthraquinones and anthrones. Clinical trial in new cases of diabetes mellitus. Vardy AD, Cohen AD, and Tchetov T. A double-blind, placebo-controlled trial of Aloe vera (A. barbadensis) emulsion in the treatment of seborrheic dermatitis. Hepatogastroenterology 1990;37(6):601-605. J Derm Treatment 1999;10:7-11. Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. J Med Assoc Thai. 2012;18:850-3. Interventions for preventing oral mucositis for patients with cancer receiving treatment. West DP, Zhu YF. A double-blind clinical study in humans. 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